Drug trial investigators asked to declare financial interests
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چکیده
منابع مشابه
Drug trapping in hERG K+ channels: (not) a matter of drug size?† †The authors declare no competing interests.
Inhibition of hERG K channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmias and sudden cardiac death. The capture of drugs behind closed channel gates, so-called drug trapping, is suggested to harbor an increased pro-arrhythmic risk. In this study, the trapping mechanisms of a trapped hERG blocker propafenone and...
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ژورنال
عنوان ژورنال: BMJ
سال: 1999
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.318.7187.831